all MUGEN mice

PI3Kgamma, p110gamma


General Information
MUGEN ID
M141005
Common Line Name
PI3Kgamma, p110gamma
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Garlanda Cecilia
Institution
HUMANITAS
Research Applications Comments
Tool used to study leukocyte migration

Availability
Repository Available Background State Type
HUMANITAS 129x1/SvJ live mouse mutant strain
Charles River Italy 129x1/SvJ live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
LacZ, IRES; neo, bacterial 129P2/OlaHsd C57BL/6J C57BL/6J >=10

Strain Information
Designation
B6;129-Pik3cgtm1Wym

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Matthias P Wymann Pik3cgtm1Wym targeted mutation

Gene(s)
Name Comment Chromosome
phosphoinositide-3-kinase, catalytic, gamma polypeptide not provided yet 12

Handling & Genotyping Instructions
Name Type
Docs
PCR protocol - PI3Kgamma p110gamma.docFile

Mammalian Phenotype Ontologies
 
MP Term: muscle phenotype>abnormal muscle physiology>abnormal muscle contractility>abnormal cardiac muscle contractility>increased cardiac muscle contractility
PATO Logical Definition:  increased contractility inheres_in heart myocardium
 
MP Term: cardiovascular system phenotype>abnormal cardiovascular system physiology>abnormal cardiac muscle contractility>increased cardiac muscle contractility
PATO Logical Definition:  increased contractility inheres_in heart myocardium
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal immune cell physiology>abnormal antigen presenting cell physiology>abnormal macrophage physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in macrophage
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal adaptive immunity>abnormal cell-mediated immunity>abnormal leukocyte physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in leukocyte
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal adaptive immunity>abnormal cell-mediated immunity>abnormal leukocyte physiology>abnormal granulocyte physiology>abnormal neutrophil physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in neutrophil
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal adaptive immunity>abnormal cell-mediated immunity>abnormal leukocyte physiology>abnormal granulocyte physiology>defective granulocyte chemotaxis
PATO Logical Definition: 
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal adaptive immunity>abnormal antigen presenting cell physiology>abnormal macrophage physiology>abnormal macrophage recruitment>decreased macrophage recruitment
PATO Logical Definition:  decreased inheres_in nuclear chromosome
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal response to infection>altered susceptibility to infection>increased susceptibility to infection>increased susceptibility to bacterial infection
PATO Logical Definition:  decreased inheres_in defense response to bacterium
 
MP Term: hematopoietic system phenotype>abnormal hematopoietic system morphology/development>abnormal blood cell morphology/development>abnormal white blood cell number>increased white blood cell number>increased granulocyte number>increased neutrophil cell number
PATO Logical Definition:  increased number inheres_in neutrophil
 

References
Name Type Comment
Hirsch et al., 2000 Science 287(5455):1049-53 Webblink Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

Author's Comments
 
Pik3cgamma is a crucial signaling molecule required for macrophage accumulation in inflammation