all MUGEN mice

pentraxin 3, TSG-14


General Information
MUGEN ID
M141006
Common Line Name
pentraxin 3, TSG-14
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Garlanda Cecilia
Institution
HUMANITAS
Research Applications Comments
Tool used to study innate immune responses

Availability
Repository Available Background State Type
HUMANITAS C57BL/6J live mouse mutant strain
HUMANITAS 129/Sv live mouse mutant strain
Charles River Italy C57BL/6J live mouse mutant strain
Charles River Italy 129/Sv live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
LacZ, IRES; neo, bacterial 129/Sv C57BL/6J C57BL/6J >=10

Strain Information
Designation
B6;129-Ptx3tm1Mant

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Alberto Mantovani Ptx3tm1Mant targeted mutation

Gene(s)
Name Comment Chromosome
pentraxin related gene not provided yet 3

Handling & Genotyping Instructions
Name Type
Docs
PCR protocol pentraxin 3 TSG-14.docFile

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Garlanda et al., Nature 2002 420(6912):182-6 Webblink Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.

Author's Comments
 
Ptx3 has a non-redundant role in resistance to selected microbial agents, in female fertility and inflammatory responses