all MUGEN mice

TIR8


General Information
MUGEN ID
M141007
Common Line Name
TIR8
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Garlanda Cecilia
Institution
HUMANITAS
Research Applications Comments
Tool used to study inflammation and innate immune responses

Availability
Repository Available Background State Type
HUMANITAS C57BL/6J live mouse mutant strain
Charles River Italy C57BL/6J live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129/Sv C57BL/6J C57BL/6J C57BL/6J >=10

Strain Information
Designation
B6-Sigirrtm1Mant

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Alberto Mantovani Sigirrtm1Mant targeted mutation

Gene(s)
Name Comment Chromosome
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain not provided yet 7

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system cell morphology>abnormal immune cell development>abnormal leukopoiesis>abnormal myelopoiesis>abnormal myeloid dendritic cell morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in myeloid dendritic cell
 

References
Name Type Comment
Garlanda et al., 2004 PNAS 101(10):3522-6 Webblink Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family.

Author's Comments
 
TIR8 represents a negative regulator of IL-1 receptor/TLR signaling in the gastrointestinal tract, in the lung, in DC