all MUGEN mice

D6-/-


General Information
MUGEN ID
M149001
Common Line Name
D6-/-
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Garlanda Cecilia
Institution
HUMANITAS
Research Applications Comments
Tool used to study inflammation and innate immune responses

Availability
Repository Available Background State Type
HUMANITAS C57BL/6J live mouse mutant strain
Charles River Italy C57BL/6J live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129/Sv 129/Sv C57BL/6J C57BL/6J >=10

Strain Information
Designation
129.B6-Ccbp2tm1Gjg

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Gerard J Graham Ccbp2tm1Gjg targeted mutation

Gene(s)
Name Comment Chromosome
chemokine binding protein 2 not provided yet 9

Handling & Genotyping Instructions
Name Type
Docs
PCR sequencing primers.docFile

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Martinez de la Torre et al, 2005 Eur J Imm 35(5):1342-6 Webblink Increased inflammation in mice deficient for the chemokine decoy receptor D6.
Jamieson et al., 2005 Nat Immunol 6(4): 403-11 Webblink The chemokine receptor D6 limits the inflammatory response in vivo.

Author's Comments
 
Complete removal of D6 coding sequence. D6 is a decoy receptor that tune tissue inflammation and control transfer of inflammatory chemokines. Non redundant role in female fertility.