all MUGEN mice

p50


General Information
MUGEN ID
M151002
Common Line Name
p50
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Garlanda Cecilia
Institution
HUMANITAS
Research Applications Comments
To study macrophages polarization and tolerance.

Availability
Repository Available Background State Type
JACKSONS C57BL/6J live mouse mutant strain
HUMANITAS C57BL/6J live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129x1/SvJ 129P2/OlaHsd C57BL/6J C57BL/6J >=10

Strain Information
Designation JAX ID
B6;129P-Nfkb1tm1Bal 002849

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, David Baltimore Nfkb1tm1Bal targeted mutation

Gene(s)
Name Comment Chromosome
nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 not provided yet 3

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system organ morphology>abnormal gut-associated lymphoid tissue morphology>abnormal Peyer's patch morphology>abnormal Peyer's patch follicle morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in peyer's patch follicle
 

References
Name Type Comment

Author's Comments
 
KO mice are viable and fertile, exhibit defective B cell responses, responses to infection, and in basal and specific antibody production. KO mice have reduced tumor growth associated to reduced immunosuppression of tumor associated macrophages.