all MUGEN mice

TgTACI-Ig


General Information
MUGEN ID
M155001
Common Line Name
TgTACI-Ig
Research Applications Type
TRANSGENIC TOOL
Contact
Schneider Pascal
Institution
UNIL
Research Applications Comments
Mouse model for B cell studies

Availability
Repository Available Background State Type
UNIL C57BL/6JOlaHsd live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
antitrypsin promoter, IgG heavy chain, TACI, human; beta-globin, rabbit; BCMA, murine B6D2F2 B6XD2 C57BL/6JOlaHsd >=10

Strain Information
Designation
B6;CB-Tg(hTACI:Fc)5508Siec

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 5508, Swiss Institute for Experimental Cancer Research Tg(TNFRSF13B-FCGR3A)5508Siec transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 5508, Swiss Institute for Experimental Cancer Research not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Schneider et al., 2001 J Exp Med 194(11):1691-7 Webblink Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.

Author's Comments
 
Transgene expresses the recombinant protein at the level of 2-4 µg/ml in the serum