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GFAP-CrePR


General Information
MUGEN ID
M173003
Common Line Name
GFAP-CrePR
Research Applications Type
TRANSGENIC TOOL
Contact
Kollias George
Institution
FLEMING
Research Applications Comments
Effective tool for generating tissue-specific targeted mutants to study astrocytes. Inducible Cre system- RU486(mifepristone).

Availability
Repository Available Background State Type
FLEMING C57BL/6JOlaHsd live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
GFAP: mouse, Cre: P1 bacteriophage, PR (progesterone receptor gene) and hGH (genomic elements): human CBXB6 CBXB6 C57BL/6JOlaHsd 07

Strain Information
Designation
B6;CB-Tg(GFAP-cre,PGR)473Gkl/Flmg

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 473, George Kollias Tg(GFAP-cre,PGR)473Gkl transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 473, George Kollias not provided yet UN

Handling & Genotyping Instructions
Name Type
Docs
PCR protocol Tg GFAP CrePR.docFile
PGR.docFile

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment

Author's Comments
 
These transgenic mice are useful for generating RU 486-induced, Cre-mediated targeted deletions.