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P14


General Information
MUGEN ID
M189001
Common Line Name
P14
Research Applications Type
TRANSGENIC TOOL
Contact
Di Santo James
Institution
PASTEUR
Research Applications Comments
Tool for analysis of anti-viral CD8+ T cell responses

Availability
Repository Available Background State Type
JACKSONS B6XD2 cryopreserved embryos mutant strain
PASTEUR C57BL/6J live mouse mutant strain
CNRS C57BL/6J live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
LCMV, B10.BR/SgSn B6D2F2 C57BL/6J >=10

Strain Information
Designation JAX ID
B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ 004694

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 327, Birgit Ledermann Tg(TcrLCMV)327Sdz transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 327, Birgit Ledermann not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Pircher et al., 1989 Nature 342(6249):559-61 Webblink Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen.

Author's Comments
 
Transgenic mice carry a T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for LCMV, H2-Db. Ten to twenty copies of the Tcr transgene were reported to have integrated on the same chromosome.