all MUGEN mice

LDLR


General Information
MUGEN ID
M191001
Common Line Name
LDLR
Research Applications Type
MODEL OF HUMAN DISEASE
Contact
Di Santo James
Institution
PASTEUR
Research Applications Comments
Metabolic defect model

Availability
Repository Available Background State Type
JACKSONS 129S7/SvEvBrd live mouse mutant strain
JACKSONS 129S7/SvEvBrd*C57BL/6 live mouse mutant strain
PASTEUR MIXED live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
neo: bacterial 129S7/SvEvBrd-Hprt1+ 129S7/SvEvBrd-Hprt1+ C57BL/6J >=10

Strain Information
Designation JAX ID
B6.129S7-Ldlrtm1Her/J 002207

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Joachim Herz Ldlrtm1Her targeted mutation

Gene(s)
Name Comment Chromosome
low density lipoprotein receptor not provided yet 9

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: homeostasis/metabolism phenotype>abnormal homeostasis>abnormal lipid homeostasis>abnormal lipid level>abnormal cholesterol level>abnormal circulating cholesterol level>abnormal circulating LDL cholesterol level>increased circulating LDL cholesterol level
PATO Logical Definition:  increased concentration towards low-density lipoprotein cholesterol inheres_in blood
 

References
Name Type Comment
Ishibashi et al., 1993 J Clin Invest 92(2):883-93 Webblink Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

Author's Comments
 
Insertion of a neo cassette into exon 4. Mice homozygous for Ldlrtm1Her mutation have elevated serum cholesterol levels (200-400mg/dl) & very high levels (2,000 mg/dl) when fed a high fat diet.