all MUGEN mice

RIP-luc


General Information
MUGEN ID
M193017
Common Line Name
RIP-luc
Research Applications Type
TRANSGENIC TOOL
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Luciferase Reporter animal model is useful for studying changes in insulin production resulting from fasting, high-fat feeding, streptozotocin treatment, or therapy using compounds that sensitize the animals to insulin, and may be used as donor animals for studying pancreatic islet transplantation.

Availability
Repository Available Background State Type
DKFZ FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Insulin promoter, rat; beta-globin, human; luciferase, firefly FVB/N FVB/N FVB/N >=10

Strain Information
Designation
FVB/N-Tg(RIP-luc)1Xen

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Xenogen Tg(RIP-luc)1Xen transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 1, Xenogen not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Smith et al., 2006 Mol Imaging 5(2):65-75 Webblink In vivo monitoring of pancreatic beta-cells in a transgenic mouse model.
Hanahan et al., 1985 Nature 315(6015):115-22 Webblink Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.

Author's Comments
 
The reporter is inducible during high-fat feeding and onset of diet-induced obesity.