all MUGEN mice

MMP-9


General Information
MUGEN ID
M193018
Common Line Name
MMP-9
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Inflammation/ECM remodelling

Availability
Repository Available Background State Type
DKFZ C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
neo: bacterial 129P2/OlaHsd C57BL/6 C57BL/6 >=10

Strain Information
Designation
B6;129P2-Mmp9tm1Arnd

Allele & Mutations
Name Symbol Mutation(s)
Mmp9, targeted mutation 1, Bernd Arnold Mmp9tm1Arnd targeted mutation

Gene(s)
Name Comment Chromosome
matrix metallopeptidase 9 not provided yet 2

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: homeostasis/metabolism phenotype>abnormal homeostasis>abnormal histamine physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in histamine
 
MP Term: cardiovascular system phenotype>abnormal cardiovascular system morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in cardiovascular system
 

References
Name Type Comment
Dubois et al., 1999 J Clin Invest 104(11):1507–1515 Webblink Resistance of young gelatinase B–deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.
Dubois et al., 2000 J Clin Invest 106(5):627-8 Webblink Gelatinase B deficiency impairs reproduction.

Author's Comments
 
These mice show augmented production of PGE-2 of COX-1 origin, and depletion of peritoneal macrophages and decreased vasopermeability. At 4 weeks of age they are significantly less susceptible to the development of EAE than their age matched controls.