all MUGEN mice

GFAP-Kb


General Information
MUGEN ID
M193023
Common Line Name
GFAP-Kb
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Antigen Presentation

Availability
Repository Available Background State Type

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
GFAP promoter & Kb gene, mouse B6D2F1 C129F1 DBA/2(H-2d) >=10

Strain Information
Designation
D2;B6-Tg(GFAP-H2-Kb)1Gjh

Allele & Mutations
Name Symbol Mutation(s)
trangene insertion 1, Gunter J. Hammerling Tg(GFAP-H2-Kb)1Gjh transgenic

Gene(s)
Name Comment Chromosome
trangene insertion 1, Gunter J. Hammerling not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Hämmerling et al., 1991 Immunol Rev 122(1):47-67 Webblink Non-Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue-Specific Expression of a Foreign MHC Class I Antigen.
Schönrich et al., 1991 Cell 65(2):293-304 Webblink Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.

Author's Comments
 
The MHC I gene Kb is expressed under the control of GFAP in cells of neuroectodermal origin outside the thymus. These mice were tolerant to Kb.