all MUGEN mice

IKK2FL


General Information
MUGEN ID
M193025
Common Line Name
IKK2FL
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pasparakis Manolis
Institution
CGN
Research Applications Comments
Inflammation/Immune Modulation

Availability
Repository Available Background State Type
EMMA C57BL/6 live mouse unknown
UNI Koeln C57BL/6 live mouse unknown

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Ikk2, mouse; neo, bacterial C57BL/6J (Bruce-4) C57BL/6 C57BL/6 >=10

Strain Information
Designation
B6;J-Ikbkbtm2.1Cgn

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 2.1, University of Cologne Ikbkbtm2.1Cgn targeted mutation

Gene(s)
Name Comment Chromosome
inhibitor of kappaB kinase beta not provided yet 8

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system organ morphology
PATO Logical Definition:  abnormal inheres_in lymph organ
 

References
Name Type Comment
Pasparakis M et al., 2002 Nature 417(6891):861-6 Webblink TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.

Author's Comments
 
Exons 6 and 7 of the IKK2 gene are were flanked by loxP sites. Deletion of exons 6 and 7, which correspond to nucleotides 389-567 of the coding IKK2 cDNA sequence, introduces premature termination codons producing an IKK2 null allele.