all MUGEN mice

Humanized mice


General Information
MUGEN ID
M193028
Common Line Name
Humanized mice
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Lanzavecchia Antonio
Institution
IRB
Research Applications Comments
Inflammatory/ infectious diseases. Model of RA.

Availability
Repository Available Background State Type
MIXED live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
HLA-DRA, HLA-DRB1, CD4, CII, human; CD3 promoter, mouse; polyA, viral D1AF1 C129F1 B10 >=10

Strain Information
Designation
B10.Cg-Tg(H2-Ea-HLA-DRA1*0101,HLA-DRB1*0401,Cd3d-CD4)1Riho

Allele & Mutations
Name Symbol Mutation(s)
trangene insertion 1, Rikard Holmdahl Tg(H2-Ea-HLA-DRA1*0101,HLA-DRB1*0401,Cd3d-CD4)1Riho transgenic

Gene(s)
Name Comment Chromosome
trangene insertion 1, Rikard Holmdahl not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
B├Ącklund et al., 2002 Proc Natl Acad Sci USA 99(15):9960-5 Webblink Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis.
Fugger et al., 1994 Proc Natl Acad Sci USA 91(13):6151-5 Webblink Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

Author's Comments
 
Incomplete T cell tolerance to a set of closely related self-determinants that are physiologically modified by posttranslational glycosylation. RA T cells predominantly recognize the immunodominant CII peptide in its glycosylated form.