all MUGEN mice

IRBP-Cre


General Information
MUGEN ID
M193032
Common Line Name
IRBP-Cre
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Retina/Pituitary cells

Availability
Repository Available Background State Type
NKI-AVL FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Cre: P1 bacteriophage, POMC promoter+P0 gene: rat, beta-globin+pA: rabbit, IRBP: human FVB/N FVB/N FVB/N >=10

Strain Information
Designation
FVB-Tg(Rbp3-cre)1Brn

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Anton Berns Tg(Rbp3-cre)1Brn transgenic

Gene(s)
Name Comment Chromosome
Rbp3-cre, transgene insertion 1, Anton Berns not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: tumorigenesis>altered tumor susceptibility/resistance
PATO Logical Definition: 
 

References
Name Type Comment
Akagi et al., 1997 Nucleic Acids Res 25(9):1766-73 Webblink Cre-mediated somatic site-specific recombination in mice.
Vooijs et al., 2002 Oncogene 21(30):4635-45 Webblink Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.

Author's Comments
 
This transgene expresses Cre recombinase under the control of a human interphotoreceptor retinoid binding protein promoter. This promoter is active in photoreceptor cells in the outer nuclear layer of the retina.