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Rosa26-Cre-ERT


General Information
MUGEN ID
M193033
Common Line Name
Rosa26-Cre-ERT
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
General, inducible (TAM)

Availability
Repository Available Background State Type
NKI-AVL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
ROSA26 locus, viral; beta globin, rabbit; cre, P1 bacteriophage; ERT, human 129Ola 129Ola C57BL/6 >=10

Strain Information
Designation
B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Brn

Allele & Mutations
Name Symbol Mutation(s)
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Anton Berns Gt(ROSA)26Sortm1(cre/Esr1)Brn targeted mutation

Gene(s)
Name Comment Chromosome
gene trap ROSA 26, Philippe Soriano not provided yet 6

Handling & Genotyping Instructions
Name Type
Docs
R26cre-ERT PCR protocol.docFile

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Vooijs et al., 2001 EMBO Rep 2(4):292-7 Webblink A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent.

Author's Comments
 
When these mice are crossed with a Cre transgenic strain, lacZ is expressed in cells/tissues where Cre is expressed. The ROSA26 promoter leads to generalized expression of lacZ during development or in the adult.