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Rosa26-Cre-ERT2


General Information
MUGEN ID
M193034
Common Line Name
Rosa26-Cre-ERT2
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
General, inducible (TAM)

Availability
Repository Available Background State Type
NKI-AVL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
ROSA26 locus, viral; beta globin, rabbit; cre, P1 bacteriophage; ERT, human 129S4/SvJae 129Ola C57BL/6 >=10

Strain Information
Designation
B6;129-Gt(ROSA)26Sortm2(cre/Esr1)Brn

Allele & Mutations
Name Symbol Mutation(s)
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Anton Berns Gt(ROSA)26Sortm2(cre/Esr1)Brn targeted mutation

Gene(s)
Name Comment Chromosome
gene trap ROSA 26, Philippe Soriano not provided yet 6

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Hameyer et al., 2007 Physiol Genomics 31(1):32-41 Webblink Toxicity of ligand-dependant Cre-recombinases and generation of a conditional Cre-deleter mouse allowing mosaic recombination in peripheral tissues.

Author's Comments
 
Knock-in deleter mouse line. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen.