all MUGEN mice

Flox-Luciferase


General Information
MUGEN ID
M193035
Common Line Name
Flox-Luciferase
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
General reporter for in vivo imaging

Availability
Repository Available Background State Type
NKI-AVL FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
beta actin promoter, mouse; luciferase gene, firefly FVB/N FVB/N >=10

Strain Information
Designation
FVB/N-Tg(Actb-luc)9Brn

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 9, Anton Berns Tg(Actb-luc)9Brn transgenic

Gene(s)
Name Comment Chromosome
Luciferase Reporter cassete not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Lyons et al., 2003 Cancer Res 63(21):7042-6 Webblink The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.

Author's Comments
 
When crossed with cre-specific strain, cre-mediated recombination results in the specific deletion of the floxed polyadenylation sequence and consequently luciferase transgene expression, driven by the same beta-actin promoter.