all MUGEN mice
Flox-Luciferase
General Information
MUGEN ID
M193035
Common Line Name
Flox-Luciferase
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
General reporter for in vivo imaging
Availability
Repository
Available Background
State
Type
NKI-AVL
FVB/N
live mouse
mutant strain
Genetic Background
DNA Origin
Targeted Background
Host Background
Backcrossing Strain
Backcrosses
beta actin promoter, mouse; luciferase gene, firefly
FVB/N
FVB/N
>=10
Strain Information
Designation
FVB/N-Tg(Actb-luc)9Brn
Allele & Mutations
Name
Symbol
Mutation(s)
transgene insertion 9, Anton Berns
Tg(Actb-luc)9Brn
transgenic
Gene(s)
Name
Comment
Chromosome
Luciferase Reporter cassete
not provided yet
UN
Handling & Genotyping Instructions
Name
Type
Mammalian Phenotype Ontologies
MP Term:
normal phenotype>
no abnormal phenotype detected
PATO Logical Definition:
References
Name
Type
Comment
Lyons et al., 2003 Cancer Res 63(21):7042-6
Webblink
The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.
Author's Comments
When crossed with cre-specific strain, cre-mediated recombination results in the specific deletion of the floxed polyadenylation sequence and consequently luciferase transgene expression, driven by the same beta-actin promoter.
