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Pten


General Information
MUGEN ID
M193037
Common Line Name
Pten
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Apoptosis

Availability
Repository Available Background State Type
EMMA FVB/N cryopreserved embryos mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Pten, mouse; neo, bacterial 129Ola FVB/N >=10

Strain Information
Designation EMMA ID
FVB;129-Ptentm1.1Mro EM:00406

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1.1, Silvia Marino Ptentm1.1Mro targeted mutation

Gene(s)
Name Comment Chromosome
phosphatase and tensin homolog not provided yet 19

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Marino et al., 2002 Development 129(14):3513-22 Webblink PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.

Author's Comments
 
Thes mice could help to uncover whether Pten has a role in cell fate determination and terminal differentiation. Insertion of LoxP sequences into the fourth and fifth intron of the Pten gene, flanking exon 5.