all MUGEN mice

Ink4a mutant


General Information
MUGEN ID
M193038
Common Line Name
Ink4a mutant
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
cell cycle

Availability
Repository Available Background State Type
NKI-AVL FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129P2/OlaHsd C57BL/6 FVB/N >=10

Strain Information
Designation JAX ID EMMA ID
FVB;129-Cdkn2atm1.1Brn 2384165 EM:00435

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1.1, Anton Berns Cdkn2atm1.1Brn targeted mutation

Gene(s)
Name Comment Chromosome
cyclin-dependent kinase inhibitor 2A not provided yet 4

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype
PATO Logical Definition: 
 

References
Name Type Comment
Krimpenfort P et al., 2001 Nature 413(6851):83-6 Webblink

Author's Comments
 
These mice carry a point mutation specifically affecting p16ink4a. It introduces a stop codon at conserved aa position 101 resulting in deletion of 4rth ankyrin repeat motif.