all MUGEN mice

Pim1/2/3


General Information
MUGEN ID
M193040
Common Line Name
Pim1/2/3
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Immune Modulation/Cancer

Availability
Repository Available Background State Type
NKI-AVL FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Pim1, 2 & 3, 129OLA; neo, hygromycin & beta geo, bacterial; PGK promoter, human 129Ola C57BL/6 FVB/N >=10

Strain Information
Designation
FVB;129-Pim3tm1Brn Pim1tm1Pwl Pim2tm1Brn

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Peter W Laird Pim1tm1Pwl targeted mutation
targeted mutation 1, Anton Berns Pim2tm1Brn targeted mutation
targeted mutation 1, Anton Berns Pim3tm1Brn targeted mutation

Gene(s)
Name Comment Chromosome
proviral integration site 1 not provided yet 17
proviral integration site 2 not provided yet X
proviral integration site 3 not provided yet 15

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Mikkers et al., 2004 Mol Cell Biol 24(13):6104-15 Webblink Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors.
Laird et al., 1993 Nucleic Acids Res 21(20):4750-5 Webblink In vivo analysis of Pim-1 deficiency.

Author's Comments
 
PIM-deficient mice although viable and fertile, they have profoundly reduced body size at birth and throughout postnatal life. They have impaired immune responses.