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BQ.ACB


General Information
MUGEN ID
M193044
Common Line Name
BQ.ACB
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
Knock-in mouse carrying rearranged heavy chain specific for the C1 B-cell epitope on mouse collagen type II. Autoimmune, arthritis

Availability
Repository Available Background State Type
ULUND C57BL/10.H2q live mouse unknown

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129Ola 129 E14 C57BL/6 C57BL/10.Aq 07

Strain Information
Designation
B10;129-Igh-VJ558tm1Riho

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Rikard Holmdahl Igh-VJ558tm1Riho targeted mutation

Gene(s)
Name Comment Chromosome
immunoglobulin heavy chain (J558 family) not provided yet 12

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Mo et al., 1993 Eur J Immunol 23(10):2503-10 Webblink Variable region gene selection of immunoglobulin G-expressing B cells with specificity for a defined epitope on type II collagen.

Author's Comments
 
The variable region of immunoglobulin heavy chain (IgH) specific for C1 epitope of CII is expressed.