all MUGEN mice

TNFRp55


General Information
MUGEN ID
M193048
Common Line Name
TNFRp55
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Inflammation/Immune Modulation

Availability
Repository Available Background State Type
JACKSONS C57BL/6 live mouse mutant strain
UNIDUESSEL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
TNFRp55, mouse; neo, bacterial 129S2/SvPas C57BL/6 C57BL/6 >=10

Strain Information
Designation JAX ID
B6;129-Tnfrsf1atm1Mak 002818

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Tak Mak Tnfrsf1atm1Mak targeted mutation

Gene(s)
Name Comment Chromosome
tumor necrosis factor receptor superfamily, member 1a not provided yet 6

Handling & Genotyping Instructions
Name Type
Links
Genotyping ProtocolWeblink

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Pfeffer et al., 1993 Cell 73(3):457-67 Webblink Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.

Author's Comments
 
TNF signaling is abolished. No TNF induction of NF-kB. Homozygous mice resistant to lethal dosages of LPS or enterotoxin but succumb to L. monocytogenes infection. Mice protected against atherosclerotic lesion development.