all MUGEN mice

LTbeta-R


General Information
MUGEN ID
M193049
Common Line Name
LTbeta-R
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Immune Modulation

Availability
Repository Available Background State Type
UNIDUESSEL B6XD2 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
LTbetaR, mouse; neo, bacterial D3 129P2/OlaHsd B6XD2 >=10

Strain Information
Designation
STOCK Ltbrtm1Kpf

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Klaus Pfeffer Ltbrtm1Kpf targeted mutation

Gene(s)
Name Comment Chromosome
lymphotoxin B receptor not provided yet 6

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in immune system
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system cell morphology>abnormal white blood cell number>increased white blood cell number>increased lymphocyte cell number>increased T cell number>increased thymocyte number
PATO Logical Definition:  increased number immature T cell
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system cell morphology>abnormal immune cell development>abnormal leukopoiesis>abnormal lymphopoiesis>abnormal B cell morphology>abnormal B cell number>increased B cell number
PATO Logical Definition:  increased number inheres_in B cell
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system organ morphology>abnormal spleen morphology>abnormal spleen size>enlarged spleen
PATO Logical Definition:  increased size inheres_in spleen
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system organ morphology>abnormal spleen morphology>abnormal spleen marginal zone morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in spleen marginal zone
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system organ morphology>abnormal lymph node morphology>abnormal Peyer's patch morphology>absent Peyer's patches
PATO Logical Definition:  lacking physical part inheres_in intestine towards peyer's patch
 

References
Name Type Comment
Futterer et al., 1998 Immunity 9(1):59-70 Webblink The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues.

Author's Comments
 
LTbeta-receptor is pivotal for ontogeny of the secondary lymoid tissues. knockout mice lack Peyer Patches, colon associated tissues and all lymph nodes.