all MUGEN mice

PUMA-G


General Information
MUGEN ID
M193050
Common Line Name
PUMA-G
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Immune Modulation

Availability
Repository Available Background State Type
UNIDUESSEL C57BL/6J live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
PUMA-G gene, mouse; LacZ, neo, bacterial 129 ES (E14) C57BL/6J >=10

Strain Information
Designation
B6;129-Gpr109atm1Soff

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Stefan Offermanns Gpr109atm1Soff targeted mutation

Gene(s)
Name Comment Chromosome
G protein-coupled receptor 109A not provided yet 5

Handling & Genotyping Instructions
Name Type
Docs
PCR primers.docFile

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Tunaru et al., 2003 Nat Med 9(3):352-5 Webblink PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

Author's Comments
 
PUMA-G deficient mice, lacking the nicotinic acid receptor indicate that this is the main mediator of the anti-lipolytic and pilid-lowering effects of nicotinic acid in vivo.