all MUGEN mice

LIGHT


General Information
MUGEN ID
M193051
Common Line Name
LIGHT
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Immune Modulation

Availability
Repository Available Background State Type
UNIDUESSEL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
light gene locus:mouse, TK:HSV cassette, neo: neomycin resistance cassette 129 ES (E14) C57BL/6 C57BL/6 >=10

Strain Information
Designation
B6;129-Tnfsf14tm1Kpf

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Klaus Pfeffer Tnfsf14tm1Kpf targeted mutation

Gene(s)
Name Comment Chromosome
tumor necrosis factor (ligand) superfamily, member 14 not provided yet 17

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system cell morphology>abnormal immune cell development>abnormal leukopoiesis>abnormal lymphopoiesis>abnormal B cell morphology>abnormal B cell number>increased B cell number
PATO Logical Definition:  increased number inheres_in B cell
 
MP Term: hematopoietic system phenotype>abnormal hematopoietic system morphology/development>abnormal spleen morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in spleen
 
MP Term: hematopoietic system phenotype>abnormal hematopoietic system morphology/development>abnormal spleen morphology>abnormal spleen marginal zone morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in spleen marginal zone
 

References
Name Type Comment
Scheu et al., 2002 J Exp Med195(12):1613-24 Webblink Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.

Author's Comments
 
"Light" is essential for costimulation in supporting T cell activation. Additionally, it cooperates with LTbeta in formation of MLNs.