all MUGEN mice

Sly


General Information
MUGEN ID
M193052
Common Line Name
Sly
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Immune Modulation

Availability
Repository Available Background State Type
UNIDUESSEL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
sly1 gene:mouse, TK:HSV C57BL/6 C57BL/6 C57BL/6 08

Strain Information
Designation
B6-1200013B08Riktm1Hlz

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Bernhard Holzmann 1200013B08Riktm1Hlz targeted mutation

Gene(s)
Name Comment Chromosome
RIKEN cDNA 1200013B08 gene not provided yet X

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system organ morphology>abnormal lymph organ development
PATO Logical Definition:  abnormal inheres_in lymph node development
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal adaptive immunity
PATO Logical Definition:  abnormal inheres_in adaptive immune response
 

References
Name Type Comment
Beer et al., 2005 Mol Cell Biol 25(21):9646-60 Webblink Impaired immune responses and prolonged allograft survival in Sly1 mutant mice.

Author's Comments
 
Mutant mice have impaired lymphoid organ development and exhibit severe defects in humoral immune responces.