all MUGEN mice

HVEM


General Information
MUGEN ID
M193053
Common Line Name
HVEM
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Inflammation/Immune Modulation

Availability
Repository Available Background State Type
UNIDUESSEL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
HVEM locus fragments:mouse, beta-galastosidase:bacterial, TK:HSV C57BL/6 C57BL/6 C57BL/6 05

Strain Information
Designation
B6-Tnfrsf14tm1Kpf

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Klaus Pfeffer Tnfrsf14tm1Kpf targeted mutation

Gene(s)
Name Comment Chromosome
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) not provided yet 4

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal immune cell physiology>abnormal leukocyte physiology>abnormal lymphocyte physiology>abnormal T cell physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in T cell
 

References
Name Type Comment
Wang Y et al., 2005 J Clin Invest 115(3):711-7 Webblink The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses.

Author's Comments
 
These mice are more susceptible to MOG peptide-induced EAE and exhibite increased morbidity and mortality to WT mice in ConA-mediated T cell-dependent autoimmune hepatitis.