all MUGEN mice

TRAP1-/-, TRAT1-/-, TRIM-/-


General Information
MUGEN ID
M193054
Common Line Name
TRAP1-/-, TRAT1-/-, TRIM-/-
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pfeffer Klaus
Institution
UNIDUESSEL
Research Applications Comments
Immune Modulation

Availability
Repository Available Background State Type
UNIDUESSEL C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
neo: bacterial 129x1/SvJ C57BL/6 C57BL/6 01

Strain Information
Designation
B6;129-Trat1tm1Lsmn

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Luca Simeoni Trat1tm1Lsmn targeted mutation

Gene(s)
Name Comment Chromosome
T cell receptor associated transmembrane adaptor 1 not provided yet 16

Handling & Genotyping Instructions
Name Type
Docs
PCR protocol.docFile

Mammalian Phenotype Ontologies
 

References
Name Type Comment
K├Âlsch et al., 2006 Mol Cell Biol 26(9):3639-48 Webblink Normal T-cell development and immune functions in TRIM-deficient mice.

Author's Comments
 
Part of exon 1 and exon 2, sequence encompassing the ATG and the entire transmembrane region, were replaced with a neomycin cassette. Western blot failed to detect protein in mutant thymocytes.