all MUGEN mice

CD2-iCre


General Information
MUGEN ID
M195005
Common Line Name
CD2-iCre
Research Applications Type
TRANSGENIC TOOL
Contact
Kioussis Dimitris
Institution
MRC-NIMR
Research Applications Comments
All T- some B lymphocytes

Availability
Repository Available Background State Type
NIMR C57BL/6 NIMR live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Codon-improved Cre; human CD2 promoter and LCR CBACaB10F1 CBACaB10F1 C57BL/6NIMR >=10

Strain Information
Designation
STOCK Tg(CD2-cre)1Kio

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Dimitris Kioussis Tg(CD2-cre)1Kio transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 1, Dimitris Kioussis not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
De Boer et al., 2003 Eur J Immunol 33(2):314-25 Webblink Transgenic mice with hematopoietic and lymphoid specific expression of Cre.

Author's Comments
 
Expression of iCre is under the control of the hCD2 promoter. Expression of hCD2-iCre was more restricted and was only seen in B cells and T cells, but not in granulocytes, monocytes or erythrocytes.