all MUGEN mice

Ink4a/Arf


General Information
MUGEN ID
M195006
Common Line Name
Ink4a/Arf
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
cell cycle

Availability
Repository Available Background State Type
EMMA FVBX129 cryopreserved embryos mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129P2/OlaHsd C57BL/6 FVB/N >=10

Strain Information
Designation
FVB;129-Cdkn2atm2.1Brn

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 2.1, Anton Berns Cdkn2atm2.1Brn targeted mutation

Gene(s)
Name Comment Chromosome
cyclin-dependent kinase inhibitor 2A not provided yet 4

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Krimpenfort et al., 2001 Nature 413(6851):83-6 Webblink Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

Author's Comments
 
Cdkn2atm2Brn mice were bred with transgenic mice expressing cre recombinase (Deleter-Cre mice). This resulted in the excision of exons 2 and 3. The deletion of this region affects the expression of both isoforms, p16Ink4a and p19ARF.