all MUGEN mice

p53


General Information
MUGEN ID
M195007
Common Line Name
p53
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Apoptosis/Proliferation

Availability
Repository Available Background State Type
NKI-AVL FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Trp53, mouse; neo, bacterial 129P2/OlaHsd C57BL/6 FVB/N >=10

Strain Information
Designation
FVB;129-Trp53tm1.1Brn

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1.1, Anton Berns Trp53tm1.1Brn targeted mutation

Gene(s)
Name Comment Chromosome
transformation related protein 53 not provided yet 11

Handling & Genotyping Instructions
Name Type
Links
Genoytping protocolWeblink

Mammalian Phenotype Ontologies
 
MP Term: tumorigenesis>altered tumor susceptibility/resistance>abnormal tumor incidence>increased tumor incidence
PATO Logical Definition:  increased inheres_in neoplasia
 

References
Name Type Comment
Jonkers et al., 2001 Nat Genet 29(4):418-25 Webblink Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

Author's Comments
 
This allele is a derivative of Trp53tm1Brn in which the loxP flanked sequences were deleted in the germline by crossing mice carrying this allele to mice carrying the TgN(CMV-Cre)1Cgn transgene