all MUGEN mice

BQ.MMC, C3H.Q.MMC


General Information
MUGEN ID
M195008
Common Line Name
BQ.MMC, C3H.Q.MMC
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
Tolerance/regulation, arthritis

Availability
Repository Available Background State Type
ULUND C3H.Q live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Col2a1 gene, mouse B6D2F2 C3H.Q C3H.Q >=10

Strain Information
Designation
C3-Tg(Col2a1)1Vuo

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Eero Vuorio Tg(Col2a1)1Vuo transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 1, Eero Vuorio not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Malmstrom et al., 1996 Proc Natl Acad Sci USA 93(9):4480-5 Webblink Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
Metsäranta et al., 1992 J Cell Biol 118(1):203-12 Webblink Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain.

Author's Comments
 
Human/rat collagen type II T-cell epitope expressed inside the mouse collagen type II gene. Cartilage specific expression.