all MUGEN mice

Des.TCR


General Information
MUGEN ID
M197003
Common Line Name
Des.TCR
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
TCR transgenic

Availability
Repository Available Background State Type
DKFZ B10.BR live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
B10.BR B6D2F1 Swiss mice B10.BR >=10

Strain Information
Designation
STOCK Tg(KB5.C20-TCR)

Allele & Mutations
Name Symbol Mutation(s)
Tg(KB5.C20-TCR) Tg(KB5.C20-TCR) transgenic

Gene(s)
Name Comment Chromosome
Tg(KB5.C20-TCR) not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Schönrich et al., 1991 Cell 65(2):293-304 Webblink Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.
Hue et al., 1990 J Immunol 144(11):4410-9 Webblink A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process.

Author's Comments
 
Des-TCR mice (H-2Kk) are trangenic for a Kb-specific TCR. KB5.C20 TCR expression in thymocytes.