all MUGEN mice

Tie2-Cre


General Information
MUGEN ID
M199003
Common Line Name
Tie2-Cre
Research Applications Type
TRANSGENIC TOOL
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Endothelium/bone marrow-derived cells

Availability
Repository Available Background State Type
DKFZ CBXD2 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Tie2 promoter and intron 1, mouse; Cre, bacteriophage P1; polyA, SV40 129 ES (E14) C57BL/6 CBXD2 >=10

Strain Information
Designation
STOCK Tg(Tek-Cre)1Arnd

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Bernd Arnold Tg(Tek-cre)1Arnd transgenic

Gene(s)
Name Comment Chromosome
Tie2, transgene insertion 1, Berns Arnold not provided yet UN

Handling & Genotyping Instructions
Name Type
Docs
PCR primers.docFile

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Constien et al., 2001 Genesis 30(1):36-44 Webblink Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line.

Author's Comments
 
Tie2Cre mice facilitate gene targeting in endothelial and hematopoietic cells. All endothelial cells showed high efficiency of recombination and in the majority of hematopoietic cells but was absent in other tissues.