all MUGEN mice

RIP-Tag


General Information
MUGEN ID
M199004
Common Line Name
RIP-Tag
Research Applications Type
MODEL OF HUMAN DISEASE
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Multiple

Availability
Repository Available Background State Type
DKFZ C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Insulin promoter, rat; SV40 large T antigen (Tag), viral B6JF1 DBA2/J C57BL/6J >=10

Strain Information
Designation
STOCK Tg(RIP1-Tag)2Dh

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 2, Douglas Hanahan Tg(RIP1-Tag)2Dh transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 2, Douglas Hanahan not provided yet 2

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: endocrine/exocrine gland phenotype>abnormal gland morphology>abnormal pancreas morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in pancreas
 

References
Name Type Comment
Hanahan et al., 1985 Nature 315(6015):115-22 Webblink Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.
Adams et al., 1987 Nature 325(6101):223-8 Webblink Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells.
Ryschich et al., 2002 Int J Cancer 97(6):719-25 Webblink Transformation of the microvascular system during multistage tumorigenesis.

Author's Comments
 
Transgenic mice express the oncogene SV40 T antigen (Tag) under the control of the rat insulin gene promoter (RIP) and display distinct stages of tumor progression: onset of hyperproliferation, induction of angiogenesis and formation of solid tumors.