all MUGEN mice

IKK1FL


General Information
MUGEN ID
M199006
Common Line Name
IKK1FL
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Pasparakis Manolis
Institution
CGN
Research Applications Comments
Inflammation/Immune Modulation

Availability
Repository Available Background State Type
CGN C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
C57BL/6 Bruce 4 of C57B/6 origin C57BL/6 C57BL/6 >=10

Strain Information
Designation
B6-Chuktm1Mpa

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Manolis Pasparakis Chuktm1Mpa targeted mutation

Gene(s)
Name Comment Chromosome
conserved helix-loop-helix ubiquitous kinase not provided yet 19

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Gareus et al., 2007 Nat Cell Biol 9(4):461-9 Webblink Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.

Author's Comments
 
Mice with conditional loxP-flanked IKK1 alleles. Exons 6 through 8 were flanked by loxP sites. Deletion of loxP-flanked exons by Cre-mediated recombination leads to out-of-frame splicing of exons 5 to 9 generating an Ikk1-null allele.