all MUGEN mice

Actin-Cre


General Information
MUGEN ID
M199007
Common Line Name
Actin-Cre
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Germline Deleter

Availability
Repository Available Background State Type
JACKSONS FVB/N cryopreserved embryos mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
beta-actin promoter, human; cre, P1 bacteriophage FVB/N FVB/N FVB/N >=10

Strain Information
Designation JAX ID
FVB/N-Tg(ACTB-cre)2Mrt/J 003376

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 2, Gail R Martin Tg(ACTB-cre)2Mrt transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 2, Gail R Martin not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Lewandoski et al., 1997 Cold Spring Harb Symp Quant Biol 62:159-68 Webblink Analysis of Fgf8 gene function in vertebrate development.

Author's Comments
 
Cre recombinase expressed under the control of a human beta-actin promoter, which is active in all embryonic cells at or before the blastocyst stage. Useful as a "deletor" mouse for virtually any genomic sequence flanked by loxP sites.