all MUGEN mice

BQ.TSC


General Information
MUGEN ID
M199009
Common Line Name
BQ.TSC
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
Tolerance/regulation, arthritis

Availability
Repository Available Background State Type
ULUND C57BL/10.H2q cryopreserved embryos unknown

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
proa1(II) collagen gene, mouse C3H.Q C3H.Q C57BL/10 >=10

Strain Information
Designation
B10;C3-Col2a1tm1(SOX9)Crm

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Benoit de Crombrugghe Col2a1tm1(SOX9)Crm transgenic

Gene(s)
Name Comment Chromosome
procollagen, type II, alpha 1 not provided yet 15

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Malmström et al., 1996 Proc Natl Acad Sci USA 93(9):4480-5 Webblink Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
Garofalo et al., 1991 Proc Natl Acad Sci USA 88(21):9648-52 Webblink Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.

Author's Comments
 
Human/rat collagen type II T-cell epitope expressed inside the mouse collagen type I gene. Systemic expression