all MUGEN mice

CRP.Kb


General Information
MUGEN ID
M201003
Common Line Name
CRP.Kb
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Antigen Presentation

Availability
Repository Available Background State Type
DKFZ C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
C-reactive protein, human; Kb, mouse B6JF2 C57BL/6 >=10

Strain Information
Designation
STOCK Tg(CRP-Kb)1Gjh

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Gunter J. Hammerling Tg(CRP-Kb)1Gjh transgenic

Gene(s)
Name Comment Chromosome
transgene insertion 1, Gunter J. Hammerling not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Ferber et al., 1994 Science 263(5147):674-6 Webblink Levels of peripheral T cell tolerance induced by different doses of tolerogen.
Ciliberto et al., 1987 EMBO J 6(13):4017-22 Webblink Inducible and tissue-specific expression of human C-reactive protein in transgenic mice.

Author's Comments
 
CRP expressed exclusively in hepatocytes and induced by LPS and IL-6.