all MUGEN mice

Erp57 floxed


General Information
MUGEN ID
M201005
Common Line Name
Erp57 floxed
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
MHC transporter

Availability
Repository Available Background State Type
DKFZ C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
ERp57, 129/Sv; neo, bacterial 129P2/OlaHsd BALB/c C57BL/6 >=10

Strain Information
Designation
B6;129-Pdia3tm1Gjh

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Gunter J Hammerling Pdia3tm1Gjh targeted mutation

Gene(s)
Name Comment Chromosome
protein disulfide isomerase associated 3 not provided yet 2

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal immune cell physiology>abnormal leukocyte physiology>abnormal lymphocyte physiology>abnormal B cell physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in B cell
 

References
Name Type Comment
Garbi et al., 2006 Nat Immunol 7(1):93-102 Webblink Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57.

Author's Comments
 
Death in utero caused by ubiquitous ERp57 deletion is prevented by specific deletion in the B cell compartment. ERp57 is central for recruitment of MHC class I molecules into the loading complex.