all MUGEN mice
Erp57 floxed
General Information
MUGEN ID
M201005
Common Line Name
Erp57 floxed
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
MHC transporter
Availability
Repository
Available Background
State
Type
DKFZ
C57BL/6
live mouse
mutant strain
Genetic Background
DNA Origin
Targeted Background
Host Background
Backcrossing Strain
Backcrosses
ERp57, 129/Sv; neo, bacterial
129P2/OlaHsd
BALB/c
C57BL/6
>=10
Strain Information
Designation
B6;129-Pdia3
tm1Gjh
Allele & Mutations
Name
Symbol
Mutation(s)
targeted mutation 1, Gunter J Hammerling
Pdia3
tm1Gjh
targeted mutation
Gene(s)
Name
Comment
Chromosome
protein disulfide isomerase associated 3
not provided yet
2
Handling & Genotyping Instructions
Name
Type
Mammalian Phenotype Ontologies
MP Term:
immune system phenotype>abnormal immune system physiology>abnormal immune cell physiology>abnormal leukocyte physiology>abnormal lymphocyte physiology>
abnormal B cell physiology
PATO Logical Definition:
functionality
qualifier
abnormal
inheres_in
B cell
References
Name
Type
Comment
Garbi et al., 2006 Nat Immunol 7(1):93-102
Webblink
Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57.
Author's Comments
Death in utero caused by ubiquitous ERp57 deletion is prevented by specific deletion in the B cell compartment. ERp57 is central for recruitment of MHC class I molecules into the loading complex.