all MUGEN mice

AlbTag


General Information
MUGEN ID
M201006
Common Line Name
AlbTag
Research Applications Type
MODEL OF HUMAN DISEASE
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
Multiple

Availability
Repository Available Background State Type
ULUND C3 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
albumin promoter/enhancer, mouse; Tag, SV40 viral B6D2F1 B6D2F1 C3HeBFe >=10

Strain Information
Designation
STOCK Tg(Alb-Tag)1Gjh

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Gunter J. Hammerling Tg(Alb-Tag)1Gjh transgenic

Gene(s)
Name Comment Chromosome
Tg(Alb-Tag)1Gjh not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Ryschich et al., 2006 Cancer Res 66(1):198 Webblink Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma

Author's Comments
 
AlbTag mice express the oncogene SV40 large T antigen (Tag) under the control of albumin promoter. AlbTag mice live ~16wks. Angiogenesis is central to liver tumor progression. Liver has unique microvascular system. Tumors have increased vessel caliber.