all MUGEN mice

Vav-iCre


General Information
MUGEN ID
M201007
Common Line Name
Vav-iCre
Research Applications Type
TRANSGENIC TOOL
Contact
Kioussis Dimitris
Institution
MRC-NIMR
Research Applications Comments
All haematopoietic

Availability
Repository Available Background State Type
NIMR C57BL/6 NIMR live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Codon improved Cre recombinase, vav-hCD4 expression cassette CBACaB10F1 CBACaB10F1 C57BL/6NIMR >=10

Strain Information
Designation
STOCK Tg(Vav1-cre)1Kio

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 1, Dimitris Kioussis Tg(Vav1-cre)1Kio transgenic

Gene(s)
Name Comment Chromosome
trangene insertion 1, Dimitris Kioussis not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
De Boer et al., 2003 Eur J Immunol 33(2):314-25 Webblink Transgenic mice with hematopoietic and lymphoid specific expression of Cre.

Author's Comments
 
This transgene expresses Cre recombinase under the control of a vav promoter. This promoter was shown to be active in lymph nodes, thymus, spleen, Peyer's patches, intestinal cryptopatches, ovaries and testes.