all MUGEN mice

GFAP-Cre


General Information
MUGEN ID
M201009
Common Line Name
GFAP-Cre
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Neuronal precursors and Glia cells

Availability
Repository Available Background State Type
EMMA FVB/N cryopreserved embryos mutant stock

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
GFAP promoter and part of exon 1:mouse,Cre:P1 Bacteriophage,pA and splice sites:SV40 FVB/N FVB FVB >=10

Strain Information
Designation
FVB-Tg(Gfap-cre)2Brn

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 2, Anton Berns Tg(Gfap-cre)2Brn transgenic

Gene(s)
Name Comment Chromosome
Tg(Gfap-cre)2Brn not provided yet UN

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Marino et al., 2000 Genes Dev 14(8):994-1004 Webblink Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.
Johnson et al., 1995 Glia 13(3):174-84 Webblink Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.

Author's Comments
 
Cre expression follows the specific expression behavior typical of the GFAP promoter.