all MUGEN mice

Tapasin


General Information
MUGEN ID
M205001
Common Line Name
Tapasin
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Haemmerling Guenter
Institution
DKFZ
Research Applications Comments
MHC transporter

Availability
Repository Available Background State Type
DKFZ C57BL/6 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
tapasin gene, mouse; neo, bacterial 129 E14 C57BL/6 C57BL/6 >=10

Strain Information
Designation
B6;129-Tapbptm1Gjh

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Gunter J Hammerling Tapbptm1Gjh targeted mutation

Gene(s)
Name Comment Chromosome
Tap binding protein not provided yet 17

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system cell morphology>abnormal white blood cell number>decreased white blood cell number>decreased lymphocyte cell number>decreased T cell number
PATO Logical Definition:  decreased number inheres_in T cell
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal immune cell physiology>abnormal leukocyte physiology>abnormal lymphocyte physiology>abnormal T cell physiology>abnormal CD8+ T cell physiology>abnormal cytotoxic T cell physiology>defective cytotoxic T cell cytolysis
PATO Logical Definition:  disfunctional inheres_in T cell mediated cytotoxicity
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal immune cell physiology>abnormal leukocyte physiology>abnormal lymphocyte physiology>abnormal NK cell physiology
PATO Logical Definition:  functionality qualifier abnormal inheres_in natural killer cell
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal antigen presentation>abnormal antigen presentation via MHC class I
PATO Logical Definition:  abnormal inheres_in antigen processing and presentation of lipid antigen via MHC class Ib
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal antigen presentation>abnormal antigen presentation via MHC class I>abnormal level of surface class I molecules>decreased level of surface class I molecules
PATO Logical Definition:  decreased concentration towards MHC class I molecule
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal adaptive immunity>abnormal antigen presenting cell physiology>abnormal dendritic cell physiology>abnormal dendritic cell antigen presentation
PATO Logical Definition:  abnormal inheres_in dendritic cell antigen processing and presentation
 
MP Term: hematopoietic system phenotype>abnormal hematopoietic system morphology/development>abnormal blood cell morphology/development>abnormal hematopoiesis>abnormal leukopoiesis>abnormal mononuclear leukocyte morphology/development>abnormal lymphocyte morphology>abnormal lymphocyte cell number>decreased lymphocyte cell number
PATO Logical Definition:  decreased number inheres_in lymphocyte
 

References
Name Type Comment
Garbi et al., 2000 Nat Immunol 1(3):234-8 Webblink Impaired immune responses and altered peptide repertoire in tapasin-deficient mice.

Author's Comments
 
These mice have a disrupted tapasin gene and display reduced MHC class I expression. They have impaired CTL responses to viruses, NKs are self-tolerant, and dendritic cells do not present Ags via MHC class I pathway.