all MUGEN mice

CD2-rtTA


General Information
MUGEN ID
M205002
Common Line Name
CD2-rtTA
Research Applications Type
TRANSGENIC TOOL
Contact
Kioussis Dimitris
Institution
MRC-NIMR
Research Applications Comments
T & B cells, inducible (Dox)

Availability
Repository Available Background State Type
NIMR CBXB10 live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Reverse tetracycline operon; human CD2 promoter and LCR CBACaB10F1 Swiss mice CBACaB10F1 >=10

Strain Information
Designation
CB;B10-CD2tm1Kio

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Dimitris Kioussis CD2tm1Kio transgenic, targeted mutation

Gene(s)
Name Comment Chromosome
targeted mutation 1, Dimitris Kioussis not provided yet 3

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: normal phenotype>no abnormal phenotype detected
PATO Logical Definition: 
 

References
Name Type Comment
Lang et a., 1988 EMBO J 7(6):1675-82 Webblink The structure of the human CD2 gene and its expression in transgenic mice.

Author's Comments
 
Mice expressed the transgene in thymus and, to a lesser extent, in spleen.