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K14-CreBrn


General Information
MUGEN ID
M205004
Common Line Name
K14-CreBrn
Research Applications Type
TRANSGENIC TOOL
Contact
Berns Anton
Institution
NKI-AVL
Research Applications Comments
Epithelial cells

Availability
Repository Available Background State Type
Charles River Italy FVB/N live mouse mutant strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
K14 promoter:human, beta globin intron:rabbit, hGH pA: human, Cre:P1 bacteriophage FVB/N FVB/N FVB/N >=10

Strain Information
Designation
FVB-Tg(KRT14-cre)8Brn

Allele & Mutations
Name Symbol Mutation(s)
transgene insertion 8, Anton Berns Tg(KRT14-cre)8Brn transgenic

Gene(s)
Name Comment Chromosome
KRT14-cre, transgene insertion 8, Anton Berns not provided yet UN

Handling & Genotyping Instructions
Name Type
Links
Genotyping ProtocolWeblink

Mammalian Phenotype Ontologies
 

References
Name Type Comment
Jonkers et al., 2001 Nat Genet 29(4):418-25 Webblink Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

Author's Comments
 
Keratin 14 promoter drives Cre expression mostly in skin, coat and nail epithelium.