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BQ.Cia9


General Information
MUGEN ID
M209010
Common Line Name
BQ.Cia9
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
Affects CIA severity

Availability
Repository Available Background State Type
ULUND C57BL/10.H2q live mouse congenic strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
NOD B10.Q-H2q/SgJ C57BL/10.Aq >=10

Strain Information
Designation
B10.Q-Cia9C57BL/10

Allele & Mutations
Name Symbol Mutation(s)
C57BL/10 Cia9C57BL/10

Gene(s)
Name Comment Chromosome
collagen induced arthritis QTL 9 not provided yet 1

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: skeleton phenotype>abnormal skeleton morphology>abnormal joint morphology>joint inflammation>arthritis>susceptibility to induced arthritis
PATO Logical Definition:  susceptible toward towards arthritis inheres_in joint
 

References
Name Type Comment
Johansson et al., 2001 Eur J Immunol 31(6):1847-56 Webblink Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes.

Author's Comments
 
This allele confers resistance to collagen induced arthritis compared to NOD.