all MUGEN mice

C9T


General Information
MUGEN ID
M211010
Common Line Name
C9T
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
Collagen type IX knockout

Availability
Repository Available Background State Type
ULUND C57BL/10.H2q live mouse unknown

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
Phosphoglycerate kinase 1 (PgK-1) promoter-neomycin gene cassette, TK:Viral BALB/c 129/Sv C57BL/10.H2Q >=10

Strain Information
Designation
B10;C-Col9a1tm1Jae

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, Rudolf Jaenisch Col9a1tm1Jae targeted mutation

Gene(s)
Name Comment Chromosome
procollagen, type IX, alpha 1 not provided yet 1

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: skeleton phenotype>abnormal skeleton morphology>abnormal cartilage morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in cartilage
 
MP Term: skeleton phenotype>abnormal skeleton morphology>abnormal skeleton extremities morphology>abnormal long bone morphology>abnormal tibia morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in tibia
 
MP Term: skeleton phenotype>abnormal skeleton morphology>abnormal skeleton extremities morphology>abnormal long bone morphology>abnormal femur morphology
PATO Logical Definition:  morphology qualifier abnormal inheres_in femur
 
MP Term: skeleton phenotype>abnormal skeleton morphology>abnormal joint morphology
PATO Logical Definition:  abnormal inheres_in joint
 

References
Name Type Comment
Fassler et al., 1994 Proc Natl Acad Sci USA 91(11):5070-4 Webblink Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.
Carlsen S et al., 2006 Arthritis Res Ther 8(4):R102 Webblink Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity.

Author's Comments
 
Homozygous mutant mice are viable and show no detectable abnormalities at birth but develop a severe degenerative joint disease resembling human osteoarthritis.