all MUGEN mice

BQ.Cia2a.C5


General Information
MUGEN ID
M213010
Common Line Name
BQ.Cia2a.C5
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
Affects CIA severity and C5 levels

Availability
Repository Available Background State Type
ULUND C57BL/10.H2q live mouse congenic strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
NOD B10.Q-H2q/SgJ >=10

Strain Information
Designation
NOD.Q(C3)-H2q-Cia2C57BL/10

Allele & Mutations
Name Symbol Mutation(s)
C57BL/10 Cia2C57BL/10 QTL

Gene(s)
Name Comment Chromosome
collagen induced arthritis QTL 2 not provided yet 2

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal inflammatory response>increased inflammatory response>pancreas inflammation>insulitis
PATO Logical Definition: 
 
MP Term: immune system phenotype>abnormal immune system physiology>abnormal inflammatory response>increased inflammatory response>salivary gland inflammation
PATO Logical Definition:  increased has_central_participant salivary gland inheres_in inflammatory response
 
MP Term: immune system phenotype>abnormal immune system physiology>immune tolerance>abnormal self tolerance>autoimmune response>altered susceptibility to autoimmune disorder>decreased susceptibility to autoimmune disorder>resistance to induced arthritis
PATO Logical Definition:  resistant to towards arthritis inheres_in joint
 
MP Term: immune system phenotype>abnormal immune system physiology>immune tolerance>abnormal self tolerance>autoimmune response>altered susceptibility to autoimmune disorder>decreased susceptibility to autoimmune disorder>decreased susceptibility to autoimmune diabetes
PATO Logical Definition: 
 

References
Name Type Comment
Johansson et al., 2001 Eur J Immunol 31(6):1847-56 Webblink Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes.

Author's Comments
 
Affects CIA severity and C5 levels. Mice develop mild insulitis, sialadenitis but are resistant to diabetes and resistant to CIA.